Anatomy Cailage tissue & cell junctions 695f6b5e Which one of the following makes epiphyseal cailage matrix fail to calcify? A Thyroxine B Hypervitaminosis A C Hypovitaminosis D D Hydrocoisone High-Yield Explanation In the absence of vitamin D, epiphyseal chondrocytes continue to proliferate, but their matrix does not calcify, which leads to rickets.