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Pathology General 68dd86c9

Which one of the following is the most significant risk factor for the development of gastric carcinoma?

A
Paneth cell metaplasia
B
Pyloric metaplasia
C
Intestinal metaplasia
D
Ciliated metaplasia
High-Yield Explanation
" The risk of tumor development is greatly increased in patients in whom mucosal inflammation progresses to multifocal mucosal atrophy and intestinal metaplasia"- Robbins "Serial endoscopic examinations of the stomach in patients with atrophic gastritis have documented replacement of the usual gastric mucosa by intestinal-type cells. This process of intestinal metaplasia may lead to cellular atypia and eventual neoplasia" - Harrison

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