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Pathology General 68872bce

Sections from a solid-cystic unilateral ovarian tumor in a 30-year old female show a tumor composed of diffuse sheets of small cells with doubtful nuclear grooving and scanty cytoplasm. No C -Exner bodies are seen. The ideal immunohistochemistry panel would include -

A
Vimentin, epithelial membrane antigen, inhibin, CD99
B
Desmin, S-100 protein, smooth muscle antigen, cytokeratin
C
Chromogranin, CD45, CD99, CD20
D
CD3, chromagranin, CD 45, synaptophysin
High-Yield Explanation
This patient is having granulosa cell tumor of the ovary which is characterized histologically by : Diffuse sheets of round and oval cells      Inconspicuous groove and folds in nuclei - coffee bean appearance Scant cytoplasm Granulosa cell tumor is positive for → (i) Vimentin, (ii) Inhibin, (iii) CD99 Epithelial membrane antigen is positive in surface epithelial tumor.

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