A clinical sign indicating the onset of the menopause is:

Ans. B. An increase in plasma FSH levelsOne of the first clinical measures for menopause is an increase in the serum concentration of FSH (and LH), indicative of the lack of ovarian function. Menses starts at age 12, not age 50, and its onset at this time would not indicate menopause. Excessive corpora lutea would likely indicate multiple ovulations or a failure of luteal regression. Increased vaginal cornification is an indicator of estrogen secretion, which does not occur in menopause. Menstrual cycles become irregular at menopause.