Which of the following viral markers signifies the ongoing viral replication in the case of Hepatitis-B infection?
High-Yield Explanation
HBeAg appearance- high levels of virus replication and reflects the presence of circulating intact virions and detectable HBV DNA. Patients with precore mutations cannot synthesize HBeAg In self-limited HBV infections, HBeAg becomes undetectable sholy after peak elevations in aminotransferase activity, before the disappearance of HBsAg, and anti-HBe then becomes detectable, coinciding with a period of relatively lower infectivity.