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Biochemistry General 678018c2

Which of the following does not or permissive euchromatin due to changes occurring at cytosine residues at CpG islands in DNA?

A
Methylation
B
Alkylation
C
Phosphorylation
D
Sumoylation
High-Yield Explanation
Ans: A. Methylationref: Harper's illustrated biochemistry, 30th editon., pg. 560.Methylation of cpG sites in the promoter of a gene may inhibit gene expression.There is also evidence that low folate status results in impaired methylation of cpG islands in DNA, which is a factor in the development of colorectal and other cancers.

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