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Social & Preventive Medicine General 672f6da4

Which of the following drugs used to treat MDR TB can cause hypothyroidism:

A
Kanamycin
B
Pyrazinamide
C
Ethionamide
D
None of the above
High-Yield Explanation
Adverse effects of Ethionamide Gastro-intestinal: epigastric discomfo, anorexia, nausea, metallic taste, vomiting, excessive salivation, and sulfurous belching Psychiatric: hallucination and depression Hepatitis Hypothyroidism and goitre with prolonged administration Gynaecomastia, menstrual disturbances, impotence, acne, headache, and peripheral neuropathy Ref:

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