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Physiology G.I.T 665ff281

Which of the following is the pacemaker of the gastrointestinal tract?

A
P cells
B
Oxyntic cells
C
Interstitial cells of Cajal
D
Parietal cells
High-Yield Explanation
Interstitial cells of Cajal are the pacemaker cells of the GIT that initiate the basic electric rhythm(BER). These are stellate mesenchymal pacemaker cells with smooth muscle-like features. In the stomach and the small intestine, these cells are located in the circular smooth muscle layer near the myenteric plexus. In the colon, they are at the submucosal border of the circular muscle layer. Ref: Ganong&;s review of Medical physiology 26th edition Pgno: 494-495

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