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Pathology General 663ad392

A 55 years old female patient is presenting with excessive menstrual blood loss and fecal blood loss. The diagnosis is

A
Gardner syndrome
B
Turcot's syndrome
C
Lynch syndrome
D
None of the above
High-Yield Explanation
Answer- C. Lynch syndromeLynch syndrome is characterized by colorectal, endometrium and ovarian carcinomas.Hereditary non-polyposis colorectal cancer (HNPCC) syndromeIt is also known as Lynch syndrome. It is characterized by increased incidence of colorectal cancer and extraintestinal cancers (ovary and endometrium).There is mutation in MSH2 and MLH1 genes required for DNA repair. This causes mictosatellite instability.Colon cancer in these patients affect ascending (right) colon.

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