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Ophthalmology General 662905bb

Skin depigmentation, bilateral uveitis and tinnitus are features of –

A
Vogt Koyanagi harada syndrome
B
Waardenburg Syndrome
C
Alport Syndrome
D
Werner's Syndrome
High-Yield Explanation
Vogt Koyanagi - Harada (VKH) syndrome It is an idiopathic multisystem disorder which includes cutaneous, neurological and ocular lesions. The disease is comparatively more common in Japanese who are usually positive for HLA-DR4 and DW15. Clinical features Cutaneous lesions include: alopecia, poliosis and vitiligo. Neurological lesions are in the form of meningism, encephalopathy, tinnitus, vertigo and deafness. Ocular features are bilateral chronic granulomatous anterior uveitis, posterior uveitis and exudative retinal detachment.

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