Drug distribution is influenced by:

- Factors affecting drug distribution  Lipid solubility - Higher the solubility, higher the distribution  Ionization at physiological pH - Higher the ionization, lower the distribution The degree of plasma protein binding - More the binding, less the distribution  Affinity for different tissues - Higher affinity, higher distribution  Regional blood flow - More the flow, more the distribution  Fat: lean body mass ratio (changes with age) - Increases with age  Disease like CHF, uremia, cirrhosis