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Pharmacology General 65410118

Methicillin-resistant staphylococci do not respond to β–lactam antibiotics because :

A

They produce a β–lactamase which destroys methicillin and related drugs

B

They elaborate an amidase which destroys methicillin and related drugs

C

They have acquired penicillin binding protein which has low affinity for β-lactam antibiotics

D

They are less permeable to β-lactam antibiotics

High-Yield Explanation

Resistance to most penicillins is due to elaboration of beta-lactamase. Methicillin is most resistant penicillin to β-lactamase. Staphylococcus aureus develops resistance to methicillin by the acquisition of altered penicillin-binding proteins.

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