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Pathology Systemic Pathology 64e59cb4

A 34-year-old man complains of sudden attacks of dizziness, blurred vision, and excruciating headaches of 4 months in duration. During one of these attacks, his blood pressure was 180/120 mm Hg. The patient's father had been treated for thyroid cancer about 15 years ago. Laboratory studies show normal serum levels of aldosterone, renin, and angiotensin. A 24-hour urinalysis reveals increased metanephrines. Episodic hypeension in this patient is most likely caused by a tumor in which of the following endocrine organs?

A
Adrenal
B
Kidney
C
Parathyroid
D
Pituitary
High-Yield Explanation
- Given clinical features suggests the diagnosis of Pheochromocytoma - Pheochromocytoma Arising from chromaffin cells of adrenal medulla that secretes catecholamines. Can originate in extra-adrenal sites - Paragangliomas. Clinical features are caused d/t release of catecholamines. - The other choices do not include tumors that lead to episodic hypeension.

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