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Pharmacology General 64c80ac8

Botulinum toxin blocks neuromuscular transmission by which of the following mechanism:

A
Closure of Ca++ channels at presynaptic membrane
B
Closure of Na+ channels at the postsynaptic membrane
C
Opening of K+channels at the presynaptic membrane
D
Opening of Cl– channels at the postsynaptic membrane
High-Yield Explanation
Botulinum toxin acts by inhibiting the calcium mediated exocytosis of ACh from the vesicles in the synapse.

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