Patient diagnosed as squamous cell intraepithelial lesion which of the following has the highest risk for progression to carcinoma:

Ans. is b, i.e. High grade squamous intraepithelial neoplasiaRef: Shaw 15th/ed, p402; Williams Gynae 1st/ed, p629There are various nomenclatures/classification systems for reporting of Pap smear.The one which is classically used is by WHO, which uses the terms CIN-I, CIN-II and CIN-IIIAnother system as discussed earlier is Bethesda which classified the disease as LSIL=low grade squamous intraepithelial lesion and HSIL high grade squamous intraepithelial lesion and chances of progressing to cancer are maximum with HSIL which includes CIN11, CIN111 and ca in situ.