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Surgery General 640a5a90

Which of the following has the least malignant potential?

A
Adenomatous polyps in HNPCC
B
Juvenile polyps in Juvenile Polyposis Syndrome
C
Adenomatous Polyps in Familial colonic Polyposis
D
Hamaomatous Polyps in Peutz Jegher's Syndrome
High-Yield Explanation
Among the options given in the question hamaomatous polyps in Peutz Jegher's syndrome has only a small chance of being malignant (39%). Juvenile Polyps given in this question are not solitary polyps, but pa of juvenile polyposis syndrome, which has a risk of about 30 to 60 % to develop into a carcinoma. In HNPCC, there 80% lifetime risk of developing colorectal carcinoma. Adenomatous polyps in Familial adenomatous polyposis, if left untreated has a 100% relative risk of turning into malignancy. Ref: Current Surgical Diagnosis& Treatment, 12th Edition, Page 696, 697, 709, 710; Cancer Epidemiology and Prevention By David Schottenfeld, 3rd Edition Page 568; Principles and Practice of Clinical Medicine in Asia: Treating the Asian Patient By Joseph Jao Yiu Sung, page 276; Harrison's Principles of Internal Medicine 18th edition, Chapter 91.

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