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Pharmacology General 62f12b57

Amoxicillin + clavulanic acid is active against the following organisms EXCEPT :

A
Methicillin resistant Staph. aureus
B
Penicillinase producing Staph. aureus
C
Penicillinase producing N. gonorrhoeae
D
β-lactamase producing E. coli
High-Yield Explanation
Staphylococcus aureus develops resistance to methicillin by acquiring altered penicillin-binding proteins that have low affinity. No Beta-lactam antibiotic is effective against MRSA. Clavulanic acid is an inhibitor of β-lactamase. It can restore the sensitivity of penicillins against the organisms who have developed penicillinases.

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