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Pharmacology Cell Wall Synthesis Inhibitors 62b40302

Which of the following is not an established antimicrobial drug synergism at clinical level?

A
Amphotericin B and flucytosine in cryptococcal meningitis
B
Carbenicillin and gentamicin in pseudomonal infections
C
Penicillin and tetracycline in bacterial meningitis
D
Trimethoprim and sulfamethoxazole in coliform infections
High-Yield Explanation
Combination of a bacteriostatic and a bactericidal drug in most cases is antagonistic. Bactericidal drugs act on fast multiplying organisms whereas bacteriostatic drugs inhibit the growth. Here, penicillins are bactericidal whereas tetracyclines are bacteriostatic.

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