A 5–year old boy presents with pubic hair development. He is tall and has increased pigmentation of his genitalia and phallic enlargement. Blood pressure is 130/90 mm g. Measurement of which of the following diagnostic? hormones would be most likely to be diagnostic?

Presence of Precocious puberty in a male child and hypertension (BP of 130/80 in a 5-year-old child is considered hypertension) suggests a diagnosis of congenital adrenal Hyperplasia due to 11-β Hydroxylase deficiency. levels and excretion of 11 deoxycortisol are increased.