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Medicine General 623642f1

Which of the following sites is responsible for the amnestic defect in Wernicke's Korsakoff syndrome:

A
Mamillary body
B
Thalamus
C
Periventricular Grey matter
D
Hippocampus
High-Yield Explanation
Answer is B (Thalamus): The Amnestic effect in Wernicke's Korsakoff Syndrome is related to lesions in the dorso-medial nuclei of the thalamus. `Lesions in the dorsomedial nucleus of the thalamus seem to be the best correlate of the memory disturbance and confabulation' - Robbins

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