Full 2L QBank
Pharmacology General 61f9f3bc

Which one of this drugs doesn't have interaction with pyridoxine?

A
Isoniazid
B
Cyclosporine
C
Levodopa
D
Hydralazine
High-Yield Explanation
Pyridoxine reduces the effect of Levodopa in the treatment of parkinsonism. It is co-decarboxylase and by facilitating decarboxylation of levodopa reduces its blood level. It interacts with isoniazid and reduces the toxicity of isoniazid in slow acetylators. The hypotensive effect of hydralazine is reduced if pyridoxine is added along with it. Ref: John Parry Griffin, P. F. D'Arcy, Patrick Francis D'Arcy (1997), Elsevier Publications, In the book, "A Manual of Adverse Drug Interactions", 5th Edition, Page 367 ; KD Tripathy, 5th Edition, Pages 823 - 824

Related Pharmacology MCQs

Practice 2,00,000+ NEET PG Questions Free

Timed mock tests, mistake queue analytics, audio lectures & zero attempt limits on i❤️Exams.

Start Free Mock Test Now