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Biochemistry Chemistry of Lipids 61a768a1

Which of the following phospholipid is predominantly found in the inner mitochondrial membrane?

A
Cardiolipin
B
Cephalin
C
Lecithin
D
Sphingomyelin
High-Yield Explanation
Cardiolipin: Diphosphatidyl glycerol i.e. 2 phosphatidic acid moieties attached to glycerol. Found in inner mitochondrial membrane. Physiological role: Increases the efficiency of the oxidative phosphorylation by acting as proton trap. Involved in signalling of apoptosis (programmed cell death). Anticoagulant Pathological role: Bah syndrome - defective biosynthesis of Cardiolipin. Antiphospholipid syndrome thrombotic condition leading to aboion. Anti-cardiolipin antibodies are found.

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