The mechanism by which smoking accelerates vascular injury is?

Smoking impacts on and potentiates the mechanisms at three separate stages of the development of vascular disease (atherosclerosis):1) Endothelial dysfunction2) Monocyte recruitment and development of the plaque3) Thrombosis at the damaged vessel wallRef: The Nature Of Disease: Pathology For The Health Professions, By Thomas H. McConnell, Page 279