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Pathology General 61988ce2

Apoptosis activating factor 1 (Apaf-1)

A
Activates caspase 9
B
Activates caspase 8
C
Activates Bcl-1 and Mcl-1
D
Binds with mitochondrial cytochrome C
High-Yield Explanation
Apaf-1 combines with cytoplasmic cytochrome C that leads to formation of apoptosome complex which further triggers caspase 9 activation. Thus, leading to apoptosis via intrinsic pathway.

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