NOT TRUE regarding sevoflurane

D i.e., Sevoflurane is less cardiodepressant than isoflurane Sevoflurane is inhalational agent of choice for inductioin of anesthesia in pediatric patients and adults, because of rapid onset of action & nonpengency Q Desflurane & isoflurane are more pungent and are associated with more coughing breath holding & laryngeal spasm during inhalational inudction, so not used as first choiceQ. Methoryflurane is highly nephrotoxic, so not preferred. Sevoflurane is not recommended in closed circuit because there is chance of production of a toxic metabolic product compound A, Q (an olefin) in closed circuit. - Unlike isoflurane & desflurane, both of which lead to tachycaridia, sevoflurane has minimal effect on hea rate. Sevoflurane can cause direct myocardial depression ( calcium channels) and produce dose dependent depression of cardiac output, & reduction in systemic vascular resistance similar to that seen in isoflurane