With reference to the optimal management of patients with sepsis in the intensive care unit, all of the following interventions are evidence-based except:
A
Low tidal volume during assisted ventilation prevents acute lung injury
B
For outcome of goal-oriented management of sepsis patients, monitoring of central venous pressure, hourly urine output and blood pressure is adequate
C
Intensive blood glucose monitoring and prevention of hyperglycemia improves survival in critically ill patients
D
The use of drotrecogin-alpha is restricted to severely ill patients with APACHE score > 25