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Which of the following is associated with PAS positive macrophages?

A
Whipple disease
B
Abetalipoproteinemia
C
Crohns disease
D
Ulcerative colitis
High-Yield Explanation
Ref. Robbins Pathology. 9th edition. Page. 791   Whipple disease: Rare systemic infection due to Tropheryma whippelii, a gram positive intracellular actinomycete Usually affects proximal intestine, mesenteric lymph nodes Also called intestinal lipodystrophy   Symptoms: Malabsorption with diarrhea, weight loss, abdominal pain Occasionally polyarthritis, CNS complaints, lymphadenopathy, hyperpigmentation Cardiac involvement less common   Microscopy Distended macrophages in lamina propria containing PAS+ (diastase resistant) granules and rod shaped bacilli by EM Dilated lymphatics or fat vacuoles

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