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Pathology General 60d9ccab

In which of the following type of osteogenesis imperfecta, 90% of newborn die before 4 weeks of age?

A
Type I
B
Type II
C
Type III
D
Type IV
High-Yield Explanation
Type I Osteogenesis imperfecta is the most common and the mildest form of osteogenesis imperfecta.  Around 10% of the patients show prenatal fractures. Type II is the most severe form of osteogenesis imperfecta, with extreme bone fragility and frequent fractures. Around 90% of the cases are either stillborn or die before 4 weeks of postnatal life. Prenatal fractures are common in most of the patients. In utero fractures occur in 50% of the Type III osteogenesis imperfecta patients. The rest of the cases acquire fractures in the neonatal period. No hearing loss has been reported in this type. Reference: Shafer’s Textbook of ORAL PATHOLOGY Eighth Edition page no 458,459

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