DNA analysis of chorionic villus/amniocentesis is not likely to detect:

Ans. is a, i.e. Tay-Sachs diseaseRef. JB Sharma TB of Obs pg 161; Williams Obs 25/e, p 296Ref Operative Obs and Gynae by Randhir Puri, Narendra Malhotra 1/e, p 261, 262; Obs. and Gynae Beckmann 5/e, p 45In chorionic villous biopsy, trophoblastic tissue is obtained from the chorionic villi, followed by biochemical or molecular (DNA) analysis or chromosomal analysis of this tissue to diagnose various conditions.Conditions which require molecular or DNA analysisConditions which require biochemical analysis* Hemoglobinopathies* Sickle cell disease* Alpha thalassemia* Beta thalassemia* Hemophilia A or B* Duchenne muscular dystrophy* Cystic fibrosis* Alpha-1 antitrypsin deficiency* Tay Sach's disease* Tay Sach's disease* Niemann Pick disease* Gaucher's disease* Urea cycle defects* Amino acid disorder* Congenital adrenal hyperplasia* PhenylketonuriaFor diagnosis of Tay Sach's disease biochemical analysis and DNA analysis of chorionic villous sample is done (not DNA analysis). For rest all options only DNA analyses would do that is why I am picking that option.