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Biochemistry General 5fc7cb81

The normal cellular counterpas of oncogenes are impoant for the following functions, except ?

A
Promotion of cell cycle progression
B
Inhibition of apoptosis
C
Promotion of DNA repair
D
Promotion of nuclear transcription
High-Yield Explanation
o Normal cellular counterpa of oncogene is protooncogene.o The functions of protooncogene is to code forGrowth factorsGrowth factor receptorsProteins involved in signal transductionNeuclear regulatory proteins (transcription factors)Cyclins/CDKso All these lead to cell proliferation and progression of cell cycle.o When any of these protooncogenes becomes oncogene by mutation / overexpression, there is uncontrolled proliferation of cell and development of cancer.This proliferation is autonomous, i.e. without physiological stimulus.

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