Cough and angioedema in a patient receiving ACE inhibitor is due to

Refer kDT 6/e p 484 Angiotensin-conveing enzyme inhibitors are widely prescribed for hypeension and hea failure. These drugs are commonly associated with cough, and are less commonly associated with angioedema, which may be potentially life threatening Although data are incomplete, it appears that angiotensin-conveing enzyme inhibitors cause cough and angioedema through a cascade of effects that begins with the accumulation of kinins, and then involves arachidonic acid metabolism and nitric oxide generation. Most patients who develop either cough or angioedema from angiotensin-conveing enzyme inhibitors can tolerate angiotensin-II receptor blocking agents.