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Pharmacology Penicillin & Cephalosporin 5fb4705e

A 70 - year- old man was administered penicilline intravenously. Within 5 minutes, he developed genralised urticaria, swelling of lips, hypotension and bronchospasm. The first choice of treatment is to administer:

A
chlorphenitramine inj.
B
Epinephrine inj.
C
High dose hydrocortisone tablet
D
nebulised salbutamol
High-Yield Explanation
Ans. is 'b' i.e. epinephrine injection Urticaria, swelling of lips, hypotension and bronchospasm within 5 minutes of i.v penicillin suggests anaphylactic reaction. It's a major problem with the use of penicillin.The t/t of choice for anaphylaxis is i.v epinephrine.

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