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Surgery General 5faddd01

Which of the following statements about changes in aicular cailage with aging is not TRUE?

A
Total proteoglycan content is decreased
B
Synthesis of proteoglycans is decreased
C
Total water content of cailage is decreased
D
Enzymatic degradation of proteoglycans is increased
High-Yield Explanation
In ageing there will be no increase in enzymatic degradation of proteoglycans. The enzymatic degradation is slow and constant throughout the life. Ref: Biology of Cailage Cells, Stockwell, R.A, 1976, 1st Edition, Page 245; Osteoahritis : A companion to Rheumatology, Elsevier, 1st Edition, 2007, Page 79.

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