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Pharmacology General 5fa8b031

Which of the following statement regarding first order kinetics is true?

A
It is independent of plasma concentration
B
Tl/2 of the drug increases with dose
C
Clearance of the drug decreases with dose
D
A constant propoion of plasma concentration is eliminated
High-Yield Explanation
According to first order kinetics of elimination the rate of elimination of a drug is directly propotional to the drug concentration. Clearence of the drug remains constant and a constant fraction of drug is eliminated in unit time. Ref: Essentials of Medical Pharmacology By KD Tripathi, 5th Edition, Page 27-8

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