Apixaban is:

Ref. KDT. Page. 617 Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor (of both free and prothrombinase-bound FXa independently of antithrombin III) for the prevention and treatment of thromboembolic diseases Apixaban prolongs clotting tests such as prothrombin time (PT), INR, and activated partial thromboplastin time (aptt) Apixaban is absorbed in the stomach and small intestine 87% plasma protein bound. Apixaban mainly undergoes o-demethylation and hydroxylation to metabolites Grapefruit juice may increase apixaban serum concentration. St. John's wort will likely decrease apixaban serum concentration