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Medicine Miscellaneous 5e8e357a

What is the most likely diagnosis in this patient who was having difficulty swallowing?

A
Amyloidosis
B
Amyotrophic lateral sclerosis
C
Pellagra
D
Pernicious anemia
High-Yield Explanation
Answer B. Amyotrophic lateral sclerosisWith his difficulty swallowing, the patient's tongue atrophy represents a bulbar symptom, and is most consistent with a diagnosis of amyotrophic lateral sclerosis (ALS). The patient also had clinical and neurophysiological evidence of upper-motor-neuron and lower-motor-neuron involvement, which supported the diagnosis. ALS is associated with dysarthria, hypophonia, dysphagia, and sialorrhea in addition to relentlessly progressive disability.

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