Pediatrics New Born Infants 5e073b5d Commonest renal lesion in SLE is: A Focal proliferative B Diffuse proliferative C Membranous D Minimal change disease High-Yield Explanation b. Diffuse proliferative(Ref: Nelson's 20/e p 1176-1180, Ghai 8/e p 628)Class I is the Least common & class IV is the most common pattern of lupus nephritis.