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Physiology General 5dfc306a

C- peptide is secreted by ?

A
A cells
B
B cells
C
D cells
D
F cells
High-Yield Explanation
Ans. is 'b' i.e., B cellsInsulin is a polypeptide hormone which is synthesized as a larger preprohormone (preproinsulin).Asthepreprohormone enters the endoplasmic reticulum, 23 amino-acid signal peptide is removed and it is conveed to prohormone (proinsulin).Proinsulin is made up A and B chain connected by a connecting peptide (C-peptide or C-chain).C-peptide is detached in the granules before secretion. Normally, 90-97% of the product released from B cells is insulin along with equimolar amounts of C-peptide.Insulin is a two chain polypeptide having 51 aminoacids : The A chain has 21 while B-chain has 30-aminoacids.Half life of insulin is about 5 minutes.

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