Ophthalmology Retina 5d826514 Knudson's two stage hypothesis is for: A Glaucoma B Retinoblastoma C Optic Glioma D Meningioma High-Yield Explanation Ans. (b) RetinoblastomaRef Kanski 7/e, p. 520Deletion or inactivation of RB gene by two mutations (Knudson's two hit hypothesis) results in occurrence of retinoblastoma.