During screening for cervical cancer in a community, PAP smear of a 51 year old female shows abnormal cytology. What is the best next logical procedure?
High-Yield Explanation
Colposcopic examination of the cervix is the gold standard for assessing dysplasia, carcinoma in situ, and early invasive disease. Application of Lugol iodine can be a useful adjunct to the colposcopic examination. Normal mature squamous epithelium of the cervix and vagina contains glycogen and stains a dark brown color, whereas dysplastic cells lack glycogen and stain a light yellow color. Colposcopically directed biopsy is performed for visible abnormalities, including acetowhite change, abnormal vessels, ulceration, and papillary lesions. Ref: Reynolds R, Loar P.V., III (2010). Chapter 39. Gynecology. In Dohey G.M.(Eds), CURRENT Diagnosis & Treatment: Surgery, 13e.