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Pharmacology General 5cc8a340

True about benzodiazepines -

A
Increased release of GABA
B
Antagonzing release of GABA
C
Lorazepam is shoer acting than temazepam
D
Atropine is its antagonist
High-Yield Explanation
Ans. is 'c' i.e., Lorazepam is shoer acting than temazepam o Lorazepam has t1/2 10-20 hours, while Temazepam has t1/2 10-40 hours. About other options o BZDs do not increase or decrease the release of GABA, they bind on GABAA receptors and increase Cl- conductance --> GABA facilitatory action. o Flumazenil (not atropine) is the antagonist of BZDs.

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