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Pharmacology General 5cc33526

Which of the folloiwng topical steroid used in ophthalmology has the maximum potential to increase intraocular pressure ?

A
Hydrocoisone
B
Prednisolone
C
Dexamethasome
D
Fluoromethalone
High-Yield Explanation
Ans. is 'c' i.e., DexamethasomeThe IOP -elevating potential of steroids is as follows: dexamethasone > prednisolone > fluoromethalone > hydrocoisone > tetrahydrotriamcinalone> medrysone (after 6 weeks of dexamethasone therapy.42% have IOP > 20 mmHg and 69o have IOP > 31).The steroids with low IOP - elevating potential are fluorometholone (FMI). rimexolone (Vexol), and loteprednol (Latemas, Mrex).

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