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Pharmacology Anesthesia 5c5b9f66

A 70 kg young athlete was planned for surgery. During anesthesia,vecuronium was not available so repeated doses of succinylcholine was given intermittently up to 640mg. During recovery ,patient was not able to spontaneously respire and more limbs. What is the cause

A
Pseudocholinestrease deficiency
B
Phase 2 blockade
C
Muscle weakness due to repeated fasiculations
D
Undiagnosed muscular dystrophy
High-Yield Explanation
Refer Wiley 7/584 Succinylcholine produces a characteristic depolarising block that is associated with absence of fade in response to train-of -four and titanic stimulation, the absence of post tetanic facilitation and increased block in the presence of anticholinesterase drugs. The type of block may change into a non depolarising type following prolonged admistration of drug

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