In the management of diabetes mellitus, lactic acidosis is commonly caused by which of the following: March 2005

Ans. D: Metformin Medicinal and toxic causes of lactic acidosis Acetaminophen Alcohols and glycols (ethanol, ethylene glycol, methanol, propylene glycol) Antiretroviral nucleoside analogs (zidovudine, didanosine, lamivudine) Beta-adrenergic agents (epinephrine, ritodrine, terbutaline) Biguanides (phenformin, metformin) Cocaine Cyanogenic compounds (cyanide, aliphatic nitriles, nitroprusside) Sugars and sugar alcohols (fructose, sorbitol, and xylitol), Salicylates Strychnine Sulfasalazine Valproic acid Diethyl ether, 5-fluorouracil Halothane, propofol Isoniazid