A 10 yr old boy with mass in the abdomen. On imaging the paraaortic LN is enlarged. On biopsy starry sky appearance is seen. What is the underlying abnormality?
High-Yield Explanation
Ans. (d) Translocation involving MYC gene(Ref: Robbins 9th/pg 597; 8th/607)Macrophages with abundant clear cytoplasm showing: characteristic "starry sky" pattern are seen in Burkitt lymphoma