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Biochemistry Glycogen 5b5f8f03

Which of the following substrates can't contribute to net gluconeogenesis in mammalian liver?

A
Alanine
B
Glutamate
C
Palmitate
D
Pyruvate
High-Yield Explanation
Palmitate can't contribute to net gluconeogenesis in mammalian liver Palmitate Fatty acid with 16 carbon atoms Not a substrate of gluconeogenesis. Even chain fatty acids yield Acetyl CoA upon oxidation. Odd chain fatty acid acts as a substrates of gluconeogenesis Propionyl CoA- the product of their oxidation can enter TCA cycle through formation of succinyl CoA Alanine, pyruvate and glutamate are glucogenic.

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