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Pediatrics Inborn Errors of Metabolism 5b016647

Wrinkled paper appearance of macrophage in bone marrow aspirate is seen in:

A
Niemann Pick disease
B
Gaucher disease
C
Hemophagocytic lymphohistiocytosis
D
Langerhan cell histiocytosis
High-Yield Explanation
b. Gaucher disease(Ref: Nelson's 20/e p 708-712, Ghai 8/e p 659-664)Gaucher cells are Lipid Laden Macrophages have a characteristic histologic appearance of "wrinkled tissue paper"Membrane-bound inclusions filled with glucocerebroside are seen with electron microscopy.

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