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Physiology General 5a9cd0fc

Inward flow of Na+ in heart leads to:

A
Plateau phase
B
Action potential
C
Repolarization
D
No change
High-Yield Explanation
Phase 0 (depolarization), fast sodium channels open. When the cardiac cell is stimulated and depolarizes, the membrane potential becomes more positive. Voltage-gated sodium channels (fast sodium channels) open and permit sodium to rapidly flow into the cell and depolarize it. The membrane potential reaches about +20 millivolts before the sodium channels close. Key Concept: Influx of Na+ via fast Na channel leads of phase 0 or beginning of AP in myocardium. Reference: GUYTON AND HALL TEXTBOOK OF MEDICAL PHYSIOLOGY, THIRTEENTH EDITION(INTERNATIONAL EDITION ) page no111

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