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Pharmacology Pancreas 5a8b5fad

A known case of chronic kidney disease stage 4 is on insulin therapy. What adjustment in insulin dosage is required?

A
Increase dose of insulin
B
Decrease dose of insulin
C
Variable
D
No alteration in dose
High-Yield Explanation
Some of the insulin is cleared by the kidneys. No dose adjustment is required if GFR is more than 50 mL/min. If GFR is less than 50 mL/min, then insulin dose should be reduced. As in CKD stage 4 GFR is <15mL/min so the dose of insulin should be decreased.

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