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Psychiatry General 5a55d242

Antidepressant drug that can cause neuroleptic malignant syndrome and tardive dyskinesia is:March 2009

A
Amineptin
B
Carbamazepine
C
Amoxapine
D
Trazodone
High-Yield Explanation
Ans. C: AmoxapineOne of major metabolites of amoxapine, 7-hydroxyamoxapine, has a dopamine receptor blocking effect, making this drug a common cause of neuroleptic malignant syndrome.Amoxapine is also associated with acute extrapyramidal symptoms and tardive dyskinesia.

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